Merck Associate Principal Scientist - Mass Spectrometry in Palo Alto, California

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

Merck Research Laboratories is seeking to recruit an experienced Mass Spectrometry scientist with deep and broad experience in Biologics analytical characterization (including proteins, antibodies, bispecifics and multispecifics, various proteins scaffolds, ADCs) to join the Protein Sciences Department in Palo Alto – CA.

The position will be hands-on at the bench and will initially manage one direct report (and possibly more scientists at a later point).


  • Set up and lead the Protein Sciences core mass spectrometry group.

  • Direct mass spectrometry analysis for biologics lead optimization, drug candidate selection and Protein Sciences core activities.

  • Identify, develop and implement mass spectrometry methods to characterize molecules by intact mass and peptide mapping, including data analysis, report generation, and communication of results to stakeholder and teams.

  • Collaborate with other scientists in Discovery and Development to conduct stage-appropriate developability assessments for therapeutic candidates.

  • Lead analytical subteams, technology development initiatives, and hold core team membership responsibilities.

Education Minimum Requirement:

PhD with a minimum of 4 years of relevant experience or MS degree with a minimum of 8 years of relevant experience

Required Experience and Skills:

  • Must have deep knowledge and hands-on experience with state-of-the-art technologies and methods for mass spectrometry-based analytical characterization of proteins, antibodies, bispecifics and multispecifics, various proteins scaffolds, and ADCs.

• Requires hands-on experience with Acquity/Waters QTOF, and high resolution Q-Exactive mass spectrometers platform;

• Requires experience with software platforms for intact mass deconvolution and peptide mapping analysis, including, MaxEnt I and III, UNIFI, Proteome Discoverer, MASCOT, PEAKS, Skyline, and BioPharma Finder.

  • Great attending to details and good understanding of protein structure, post-translational modifications and potential sequence liabilities (eg N- and O- glycosylation , oxidation, deamidation, clipping,…).

  • Candidate is expected to remain up-to-date on technical advancements of Mass Spectrometry instrumentation and software analysis

Preferred Experience and Skills:

  • A good understanding and working knowledge of various analytical methods for protein characterization such as SEC, IEX, RP-HPLC.

  • Excellent oral presentation and written communication.

  • Previous managerial experience.

  • Previous experience in industry

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life.

If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to .

Search Firm Representatives Please Read Carefully:

Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

Visa sponsorship is not available for this position.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster at

EEOC GINA Supplement​ at

Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Job Biology-Discovery

Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Title: Associate Principal Scientist - Mass Spectrometry

Primary Location: NA-US-CA-Palo Alto

Requisition ID: BIO005143