Merck Associate Principal Scientist, Computational Chemistry in Kenilworth, New Jersey

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

Merck is seeking a creative, self-motivated computational chemist with exceptional interpersonal and problem solving skills to join the Modeling and Informatics group in Rahway, NJ. The successful candidate will be primarily supporting programs, in collaboration with Process Research and Development, which relate to crystal structure prediction and solid-state modeling.

Key responsibilities:

  • Application and development of informatics and modeling tools applied to crystal structure prediction, computational solid-state chemistry, IR, NMR, and formulation

  • Collaborate with analytical chemistry (materials characterization and formulation groups) on the characterization of chemical entities, and leverage computational modeling to support the prediction and selection of solid form

  • Advance research in molecular modeling to enhance the drug discovery and development processes

  • Advance NMR crystallography/solid-state NMR modeling support

  • Explore formulation modeling of API-polymer interactions and peptide-surfactant systems

Qualifications:

  • Ph.D. in chemistry, physics, materials science, or a related discipline with a computational emphasis

  • 3 years or more of practical experience (pharmaceutical industry preferred)

  • Knowledge of crystallography and/or solid-state chemistry and/or solid-state NMR

  • Strong collaboration and communication skills along and the ability to work well in multidisciplinary teams are essential

  • Evidence of creative application of computational approaches to problems in solid-state modeling

  • Strong publication record

Preferred Experience and Skills:

  • Expertise in the application of quantum mechanics/density functional theory (Gaussian, Jaguar, VASP, etc.) and materials design tools (e.g. Materials Suite from Schrodinger and Materials Studio from Accelrys) for solid-state modeling

  • Familiar with Cambridge Structural Database and CCDC software applications (Conquest, Mercury, and Mogul), and experience with structural informatics

  • Proficiency with molecular modeling techniques using modern software packages (Schrodinger, OpenEye, CCG) a plus

  • Prior experience in the pharmaceutical/biotechnology industry preferred

  • Experience with scientific programming (Perl, Python, Pipeline Pilot) and data analytics (e.g., Spotfire)

  • Track record of oral presentations at national or international meetings

Education Minimum Requirement:

Ph.D. in chemistry, physics, materials science, or a related discipline with a computational emphasis

Required Experience and Skills:

3 years or more of practical experience (pharmaceutical industry preferred)

Evidence of creative application of computational approaches to problems in crystal structure prediction or solid-state modeling

Knowledge of crystallography and/or solid-state chemistry

Strong communication skills

Strong collaboration skills

Strong publication record

The ability to work well in multidisciplinary teams

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life.

If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to staffingaadar@merck.com .

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Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Job Chemistry

Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Other Locations: NA-US-NJ-Kenilworth

Title: Associate Principal Scientist, Computational Chemistry

Primary Location: NA-US-NJ-Rahway

Requisition ID: CHE006012